Key result
Co-prescription of ACE inhibitors and NSAIDs in patients over 75 years resulted in acute renal failure or deterioration in renal function in 50% (6 of 12) of exposed patients.
Why the study?
Does the co-prescription of angiotensin converting enzyme inhibitors and nonsteroidal anti-inflammatory drugs cause nephrotoxicity in patients aged over 75 years?
Population
12 patients aged over 75 years receiving a combination of angiotensin converting enzyme inhibitors and…
Design
Cohort
Follow-up
1 year
Authors
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May indicate nephrotoxicity risk with ACE inhibitor-NSAID co-prescription in elderly; hypothesis-generating and requires prospective confirmation.
Observational (n=12)
Does the co-prescription of angiotensin converting enzyme inhibitors and nonsteroidal anti-inflammatory drugs cause nephrotoxicity in patients aged over 75 years?
The combination of ACE inhibitors and NSAIDs is highly nephrotoxic in elderly patients and should be avoided, particularly in those taking diuretics.
Adhiyaman et al. (2001) conducted an observational in Patients receiving ACE inhibitors and NSAIDs (n=12). Co-prescription of Angiotensin Converting Enzyme Inhibitors and Nonsteroidal Anti-Inflammatory Drugs was evaluated on Acute renal failure or deterioration in renal function. Co-prescription of ACE inhibitors and NSAIDs in patients over 75 years resulted in acute renal failure or deterioration in renal function in 50% (6 of 12) of exposed patients.
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