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January 1, 1992Nephrology Dialysis Transplantation

Acute renal failure after the use of angiotensin-converting-enzyme inhibitors in patients without renal artery stenosis

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Why the study?

Does the combination of ACE inhibitors and diuretics/sodium depletion cause acute renal failure in patients without renal artery stenosis?

Population

27 patients treated with various angiotensin-converting-enzyme inhibitors for hypertension, heart failure…

Design

Case_series

Authors

FBFrank BridouxMHMarc HazzanJPJ.-L. Pallot

Discussion

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Overview

Supports reversible AKI from ACEi-diuretic combo without RAS; leaves open causality and generalizability.

Structured PICO

Does the combination of ACE inhibitors and diuretics/sodium depletion cause acute renal failure in patients without renal artery stenosis?

P
Population
27 patients (mean age 65 years) treated with various angiotensin-converting-enzyme (ACE) inhibitors for hypertension, heart failure, or both, without significant renal artery stenosis on angiography.
I
Intervention
Angiotensin-converting-enzyme (ACE) inhibitors combined with diuretic therapy and/or a low-salt diet.
O
Outcome
Acute renal failure and clinical recoverysafety

Sodium depletion and diuretic use can precipitate acute renal failure in patients taking ACE inhibitors, even in the absence of large renal vessel disease.

Cite This Study

Bridoux et al. (1992) studied this question.

synapsesocial.com/papers/6a8ad808a42d46e0ffca9c36https://doi.org/10.1093/oxfordjournals.ndt.a092076
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renovascular Disease and Renal Complications of Angiotensin-Converting Enzyme Inhibitor Therapy1990 · 62 citations
  2. 2Long-term follow-up of acute renal failure caused by angiotensin converting enzyme inhibitors1998 · 72 citations
  3. 3Deterioration in renal function associated with angiotensin converting enzyme inhibitor therapy is not always reversible1992 · 54 citations
  4. 4Renal Considerations in Angiotensin Converting Enzyme Inhibitor Therapy2001 · 365 citations
  5. 5Acute renal failure with ACE inhibition in aortic coarctation1994 · 9 citations