Key result
Waist circumference plus triglycerides accurately identifies metabolic syndrome in PCOS with an AUC of ~0.90.
Why the study?
No reliable and early diagnostic biomarkers for metabolic syndrome in PCOS patients have yet been identified.
Can waist circumference coupled with HDL-C or TG be used as a diagnostic marker for metabolic syndrome in Chinese women with PCOS?
Case-Control (n=401)
Can waist circumference coupled with HDL-C or TG be used as a diagnostic marker for metabolic syndrome in Chinese women with PCOS?
Effect estimate: AUC 0.882 for WC+HDL-C; AUC 0.901 for WC+TG
Waist circumference combined with either HDL-C or triglycerides provides a reliable early diagnostic marker for metabolic syndrome in Chinese women with PCOS.
WC plus HDL-C or TG shows good diagnostic accuracy in Chinese PCOS women; hypothesis-generating pending prospective validation.
Although quite a few polycystic ovary syndrome (PCOS) patients suffering from metabolic syndrome (MS) have been reported in previous studies, no reliable and early diagnostic biomarkers for MS in PCOS patients have yet been identified. To identify early and reliable diagnostic biomarkers for MS in Chinese women with PCOS, a total of 401 patients (200 PCOS patients and 201 controls) were enrolled in our present study. All of the subjects were examined for anthropometric (weight, waist circumference, blood pressure, etc.) and biochemical (fasting glucose, serum lipid indices, total testosterone, etc.) parameters. Our results showed that the prevalence of MS in the PCOS patients (20.50%) was 6.8-fold higher ( P<0.05 ) than that in the controls (2.99%). Nearly 71.0% of the PCOS patients had at least one component of MS, of which dyslipidemia was the most prevalent. Furthermore, within the PCOS group, the prevalence of MS increased with increasing age and body mass index (BMI). Logistic analysis indicated that BMI, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), hypertension, and fasting glucose were significantly associated with the presence of MS in PCOS patients. Analysis of the ability of the potential diagnostic biomarkers to indicate MS in PCOS patients showed that the PPV, NPV, specificity, sensitivity, and Youden’s index for waist circumference (WC) coupled with HDL-C were 59.68%, 97.10%, 84.28%, 90.24%, and 74.52, respectively, and those for WC coupled with TG were 93.33%, 92.35%, 98.74%, 68.29%, and 67.03%, respectively. ROC curve analysis showed that the areas under the ROC curves (AUCs) for WC coupled with HDL-C and for WC coupled with TG were 0.882 and 0.901, respectively. Our present study demonstrates that WC coupled with either HDL-C or TG can be used as a relatively early and reliable diagnostic biomarker for MS in Chinese PCOS patients.
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Sun et al. (2018) conducted a case-control in Polycystic Ovary Syndrome and Metabolic Syndrome (n=401). Waist circumference coupled with HDL-C or TG was evaluated on Diagnostic accuracy for metabolic syndrome (Area under the ROC curve) (AUC 0.882 for WC+HDL-C; AUC 0.901 for WC+TG). Waist circumference coupled with HDL-C or TG yielded high diagnostic accuracy for metabolic syndrome in Chinese women with PCOS (AUC 0.882 and 0.901, respectively).
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