Key result
Fixed orthostatic proteinuria leads to persistent proteinuria in ~49% of young men without progressive renal disease.
Why the study?
The long-term prognosis and clinical expression of fixed orthostatic proteinuria in young men remain uncertain.
Cohort (n=43)
Answers are grounded in this paper and cite their sources.
The 10-year prognosis for young men with fixed orthostatic proteinuria is excellent, with no progression to renal disease despite persistent proteinuria in nearly half.
Follow-up evaluation was carried out on 43 of 64 young men in whom a diagnosis of "fixed" orthostatic proteinuria had been established 10 years earlier. Forty-nine percent of the patients still had some type of clinical proteinura. Clinical or laboratory evidence of progressive renal disease was not found in a single patient. The 10-year prognosis of patients with this disorder is excellent, although the long-term outlook of those patients with continuing proteinura must still be regarded with some reservation. The final clinical expression of "fixed" orthostatic proteinuria has not yet been established in all patients.
No takes yet. Share an insight, caveat, or question.
Alfred L. Thompson (1970) conducted a cohort in Fixed orthostatic proteinuria (n=43). Fixed orthostatic proteinuria was evaluated on Clinical proteinuria. Fixed orthostatic proteinuria in young men resulted in persistent clinical proteinuria in 49% of patients at 10 years, with no evidence of progressive renal disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: