Key result
Systemic echovirus 11 infection caused fatal fulminant hepatic failure in a 7-day-old neonate, initially mimicking an acute metabolic decompensation.
Case Report (n=1)
No
Highlights the importance of considering systemic echovirus infection in the differential diagnosis of neonatal fulminant hepatic failure to guide appropriate family counseling.
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Echovirus PCR confirms infectious etiology in neonatal fulminant hepatic failure mimicking metabolic disease; leaves open systematic viral testing in future cases.
We report the fatal case of neonatal fulminant hepatic failure due toEchovirus infection mimicking an acute metabolic decompensation.After exclusion of several metabolic disorders, the diagnosis of theinfectious etiology was confirmed by Polymerase Chain Reaction ofEchovirus in liver and spleen tissue. Establishment of etiological diagnosisand exclusion of inherited metabolic disease helped the familycounseling regarding risk for future pregnancies. Fulminant hepaticfailure in the neonate is a diagnostic and therapeutic challenge thatrequires a multidisciplinary management. Our case illustrates thebroad differential diagnosis, the common final pathway leading to severeliver injury, and the multidisciplinary approach to diagnosis andtreatment.
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Dusica Babovic‐Vuksanovic (2011) conducted a case report in Fulminant hepatic failure (n=1). Echovirus 11 infection was evaluated on Clinical outcome. Systemic echovirus 11 infection caused fatal fulminant hepatic failure in a 7-day-old neonate, initially mimicking an acute metabolic decompensation.
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