Key result
Higher maternal red blood cell count is linked to ~63% lower congenital heart disease risk.
Why the study?
Congenital anomaly is a common cause of infant mortality in China with a high incidence, necessitating identification of potential risk factors for congenital heart diseases.
What are the maternal and paternal risk factors associated with congenital heart disease in newborns?
Observational (n=5,636)
No
What are the maternal and paternal risk factors associated with congenital heart disease in newborns?
Odds Ratio: 0.374 (95% CI 0.187–0.745)
p-value: p=0.005
Higher maternal age and gravidity are associated with increased risk of congenital heart disease, whereas higher maternal RBC count may be protective.
Background: Congenital anomaly is one of the most common cause of infant mortality and in China the incidence is quite high compared to other countries. It is therefore important to identify the potential risk factors of congenital problem such as congenital heart diseases. Materials and Methods: A retrospective study of 5,636 newborn cases from 2012 to 2014 in Panyu Maternal and Child Care Service Centre of Guangzhou was carried out, and among which 145 cases were confirmed for congenital heart defects. Review and analysis of maternal and paternal factors was performed using univariate and multivariate logistic regression analyses. Results: Several maternal factors were significantly associated with the occurrence of the congenital anomaly. However, after combining both maternal and paternal factors, only higher maternal age (OR = 1.076, 95% CI: 1.007-1.148, p = 0.029) and increased gravidity (OR = 1.153, 95% CI: 1.024-1.298, p = 0.018) were identified as risk factors whereas RBC count (OR = 0.374, 95% CI: 0.187-0.745, p = 0.005) was identified as a protective factor of the abnormal outcome using multivariate regression analysis. Conclusion: Further investigation on how the level of RBC in mother may contribute to the prevention of congenital heart disease is warranted.
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Liang et al. (2019) conducted an observational in Congenital heart disease (n=5,636). Maternal red blood cell (RBC) count was evaluated on Occurrence of congenital heart disease (OR 0.374, 95% CI 0.187-0.745, p=0.005). Higher maternal red blood cell count during pregnancy was identified as an independent protective factor against congenital heart disease (OR 0.374), while higher maternal age and gravidity increased the risk.
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