Key result
Maternal cold or fever during pregnancy significantly increased the risk of congenital heart disease in Chinese neonates (OR 4.558), alongside other identified maternal and environmental risk factors.
Why the study?
Do maternal risk factors increase the risk of congenital heart disease in Chinese neonates?
Meta-Analysis (n=7,882)
Do maternal risk factors increase the risk of congenital heart disease in Chinese neonates?
Odds Ratio: 4.558 (95% CI 2.901–7.162)
p-value: p=<0.001
Maternal factors such as gestational diabetes, decoration exposure, and early pregnancy medication use significantly increase the risk of congenital heart disease in Chinese neonates.
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May inform preconception counseling on maternal infections; leaves open causal confirmation in prospective studies.
Liu et al. (2017) conducted a meta-analysis in Congenital heart disease (n=7,882). Maternal cold or fever during pregnancy vs. No maternal cold or fever during pregnancy was evaluated on Congenital heart disease (OR 4.558, 95% CI 2.901-7.162, p=<0.001). Maternal cold or fever during pregnancy significantly increased the risk of congenital heart disease in Chinese neonates (OR 4.558), alongside other identified maternal and environmental risk factors.
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