Key result
Warfarin-induced skin necrosis is linked to congenital protein S deficiency.
Why the study?
Warfarin-induced skin necrosis is a rare complication primarily linked to protein C deficiency, with very few cases associated with congenital protein S deficiency.
Case Report
Highlights the rare association between hereditary protein S deficiency and warfarin-induced skin necrosis, providing management suggestions.
Warfarin skin necrosis incidence remains uncertain in cohorts; leaves open refined risk stratification for early anticoagulation in protein C deficiency.
Warfarin-induced skin necrosis is a rare complication of anticoagulant treatment. The incidence of this complication is undetermined, but it has been estimated to occur between 1:100 and 1:10,000 of patients treated with anticoagulants. Coumarin skin necrosis occurs almost exclusively in patients with venous thrombosis between the 3rd and 10th day after beginning anticoagulation. Although protein C deficiency is the most common underlying hypercoagulable state reportedly associated with warfarin skin necrosis, very few cases have been linked to congenital protein S deficiency. This article addresses the association of hereditary protein S deficiency and warfarin skin necrosis, and provides suggestions for management.
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Sallah et al. (1998) conducted a case report in Warfarin-induced skin necrosis and protein S deficiency. Warfarin was evaluated on Warfarin-induced skin necrosis. Warfarin-induced skin necrosis is a rare complication of anticoagulant treatment that can be linked to congenital protein S deficiency.
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