Why the study?
Does prolonged coumarin therapy cause skin necrosis in patients with inherited protein S deficiency?
Population
1 patient with inherited protein S deficiency on prolonged coumarin therapy
Design
Case_report
Authors
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May warrant vigilance for skin necrosis in protein S deficiency on coumarin; single case leaves open causality and practice changes.
Does prolonged coumarin therapy cause skin necrosis in patients with inherited protein S deficiency?
This case highlights the rare association between coumarin-induced skin necrosis and protein S deficiency, emphasizing potential drug interactions.
Goldberg et al. (1991) studied this question.
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