Why the study?
Does diclofenac administration induce coumarin necrosis in a patient on long-term acenocumarol therapy?
Population
1 patient (n=1), 75-year-old man receiving coumarin therapy (acenocumarol) for 7 years
Design
Case_report
Follow-up
2 days
Authors
Loading...
Renal effects of diclofenac may precipitate coumarin necrosis; hypothesis-generating case that should not yet change practice.
Does diclofenac administration induce coumarin necrosis in a patient on long-term acenocumarol therapy?
Acute renal insufficiency aggravated by diclofenac may precipitate transient protein C deficiency and subsequent coumarin-induced skin necrosis in patients on long-term coumarin therapy.
Muniesa et al. (2004) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: