Key result
Gated 3D MRA reliably visualizes the majority of principal coronary arteries in preclinical models.
Why the study?
The study aimed to develop cardiac-gated contrast-enhanced 3D MRA for imaging porcine coronary arteries within a single breathhold using fluoroscopic localization and bolus triggering.
Demonstrates the feasibility of using cardiac-gated contrast-enhanced 3D MRA with fluoroscopic localization and bolus triggering to image coronary arteries in a single breathhold in a porcine model.
Feasible for coronary visualization in pigs; leaves open translation and validation in humans.
The purpose of this study was to develop cardiac-gated contrast-enhanced 3D MRA for imaging the coronary arteries of pigs. Each major coronary artery was imaged individually in a single 3D slab in one breathhold. To permit acquisition within a breathhold, a limited number of partitions (12-16) were collected in a single, oblique, thin 3D slab. Typical resolution of the acquisition was 0.8 (X) x 1.6 (Y) x 1.6 (Z) mm. MR fluoroscopic localization was used to establish the 3D double-oblique orientation. Real-time MR fluoroscopy was also used to instantaneously trigger the 3D scan after detection in the aortic root of the intravenously administered contrast bolus. Six pigs were used in the study. Each pig was scanned on two separate days. Images routinely show the majority of the length of the three principal coronary arteries. Magn Reson Med 42:1159-1165, 1999.
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Kruger et al. (1999) studied this question. Cardiac-gated contrast-enhanced 3D MRA using fluoroscopic localization and bolus triggering was evaluated on Visualization of the three principal coronary arteries. Cardiac-gated contrast-enhanced 3D MRA using fluoroscopic localization and bolus triggering routinely showed the majority of the length of the three principal coronary arteries in pigs.
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