Key result
Metabolic syndrome in young ACS patients is linked to a ~13-fold higher STEMI risk.
Why the study?
Metabolic Syndrome has become prevalent among younger individuals, but its prevalence and impact on risk of Acute Coronary Syndrome in patients aged 50 years or younger were not well defined.
Does Metabolic Syndrome increase the risk of STEMI and reduce ejection fraction in younger patients (≤50 years) presenting with their first episode of ACS?
Observational (n=75)
Does Metabolic Syndrome increase the risk of STEMI and reduce ejection fraction in younger patients (≤50 years) presenting with their first episode of ACS?
Answers are grounded in this paper and cite their sources.
In younger patients (≤50 years) presenting with their first ACS, metabolic syndrome is highly prevalent and strongly associated with STEMI presentation and reduced ejection fraction.
Metabolic Syndrome (MeS) has reached epidemic proportions among younger individuals. We sought to determine the prevalence of MeS and its influence on the risk of Acute Coronary Syndrome (ACS) in a younger patient population (≤50 years old). Consecutive patients aged < 50 years hospitalized with the first episode of ACS were categorized whether or not they meet the modified NCEP-ATP III criteria for MeS.1 Diabetic patients were excluded. The control group was comprised of subjects with a de novo diagnosis of CAD but without MeS or DM. The prevalence of MeS in the initial sample of 212 patients with ACS was 26% (N=55). Of the 75 subjects included in the final analysis, 55 patients had MeS (C1) and 20 did not (C2). Mean age, sex, LDL, and Framingham risk scores were not significantly different. Patients with MeS were significantly more likely to present with STEMI (OR 12.67, 95% CI 1.98-78.40, P=0.004), and have lower ejection fractions (45±12% vs. 58±3%, p=0.0001). Among patients younger than 50 years presenting with the first episode of ACS, the prevalence of MeS was high even in the absence of traditional cardiovascular risk factors. Increased incidence of STEMI and reduced EFs were more commonly seen among individuals with MeS.
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Manankil et al. (2012) conducted an observational in Acute Coronary Syndrome (n=75). Metabolic Syndrome vs. No Metabolic Syndrome was evaluated on Presentation with STEMI (OR 12.67, 95% CI 1.98-78.40, p=0.004). Metabolic syndrome in patients under 50 with a first episode of ACS was associated with a significantly higher likelihood of presenting with STEMI (OR 12.67; 95% CI 1.98-78.40; P=0.004).
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