Key result
Extracellular vesicles show emerging potential as novel biomarkers and targeted therapeutics in cardiovascular disease.
Why the study?
The role of extracellular vesicles in cardiac physiology and heart disease is an emerging field with intriguing recent findings that require synthesis.
This review highlights the emerging potential of extracellular vesicles as biomarkers and therapeutic targets in cardiovascular disease.
EVs may enable future cardiac biomarkers or therapies; leaves open prospective validation before clinical adoption.
Extracellular vesicles (EV), including exosomes, microvesicles and apoptotic bodies, are released from numerous cell types and are involved in intercellular communication, physiological functions and the pathology of disease. They have been shown to carry and transfer a wide range of cargo including proteins, lipids and nucleic acids. The role of EVs in cardiac physiology and heart disease is an emerging field that has produced intriguing findings in recent years. This review will outline what is currently known about EVs in the cardiovascular system, including cellular origins, functional roles and utility as biomarkers and potential therapeutics.
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Danielson et al. (2014) conducted a review in Heart disease. Extracellular vesicles was evaluated. Extracellular vesicles play an emerging role in cardiac physiology and heart disease, offering potential utility as biomarkers and therapeutics.
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