Key result
Extracellular vesicles play important roles in intercellular communication in the cardiovascular system and hold potential as novel biomarkers and therapeutic vehicles for heart disease.
Extracellular vesicles are emerging as important mediators in cardiovascular physiology and pathology, with potential applications as biomarkers and therapeutics.
EVs may inform biomarker and therapeutic development in heart disease; leaves open clinical validation in prospective trials.
Extracellular vesicles (EV), including exosomes, microvesicles and apoptotic bodies, are released from numerous cell types and are involved in intercellular communication, physiological functions and the pathology of disease. They have been shown to carry and transfer a wide range of cargo including proteins, lipids and nucleic acids. The role of EVs in cardiac physiology and heart disease is an emerging field that has produced intriguing findings in recent years. This review will outline what is currently known about EVs in the cardiovascular system, including cellular origins, functional roles and utility as biomarkers and potential therapeutics.
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Kirsty et al. (2014) conducted a review in Cardiovascular Disease. Extracellular Vesicles was evaluated. Extracellular vesicles play important roles in intercellular communication in the cardiovascular system and hold potential as novel biomarkers and therapeutic vehicles for heart disease.
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