Key result
Higher warfarin doses in pregnant women with prosthetic valves are linked to increased stillbirth risk.
Why the study?
There is no consensus on the safest anticoagulation method during pregnancy for women with mechanical heart valves, and the correlation between warfarin dose and pregnancy outcomes is unclear.
Does warfarin dosage correlate with pregnancy outcomes in pregnant women with prosthetic heart valves?
Population
Pregnant women with prosthetic heart valves
Comparison
Different doses of warfarin
Design
Observational study
Authors
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May warrant cautious dosing in prosthetic valve pregnancies; leaves open optimal regimens for randomized trials.
Observational
Does warfarin dosage correlate with pregnancy outcomes in pregnant women with prosthetic heart valves?
In pregnant women with prosthetic heart valves, higher doses of warfarin are associated with a significantly increased risk of stillbirth, highlighting the need for careful dose management and monitoring.
Soma‐Pillay et al. (2011) conducted an observational in Pregnant women with prosthetic heart valves. Warfarin dosage was evaluated on Pregnancy outcome (valve thrombosis, maternal death, fetal abnormalities, stillbirth). Increasing doses of warfarin in pregnant women with prosthetic heart valves were significantly associated with an increased risk for stillbirth, but not fetal abnormalities.
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