Key result
A d.c. polarographic method accurately determined metronidazole in pharmaceutical dosage forms in the concentration range 5.0 × 10−5 - 7.0 × 10−4 M, with results in excellent agreement with the USP-XX method.
A rapid, sensitive, and accurate d.c. polarographic method was successfully developed for determining metronidazole concentration in pharmaceutical tablets.
Offers a simple polarographic assay for metronidazole; leaves open clinical adoption pending validation in biological samples.
A simple d.c. polarographic method has been developed for the determination of metronidazole in dosages forms. In Robinson - Britton buffer (pH 4.38) and in presence of 1.60 × 10−3 % Triton X-100, the drug produced a well defined 4-electron polarographic wave followed by another wave of about half the height of the first wave. The current is proportional to the concentration and permits the drug to be determined by d.c. polarography in the concentration range 5.0 × 10−5 -7.0 × 10−4 M. Results obtained by the proposed method are in excellent agreement with that provided by the USP-XX method. A rapid, sensitive and accurate polarographic method for the determination of metronidazole in the tablets which are produced locally is proposed.
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Zuhri et al. (1986) studied this question. d.c. polarography vs. USP-XX method was evaluated on Determination of metronidazole concentration. A d.c. polarographic method accurately determined metronidazole in pharmaceutical dosage forms in the concentration range 5.0 × 10−5 - 7.0 × 10−4 M, with results in excellent agreement with the USP-XX method.
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