Key result
Higher fasting insulin (OR 1.268), BMI, age, and triglycerides were significant predictors of abnormal glucose tolerance, which was present in 48.2% of women with PCOS.
Cross-Sectional (n=138)
No
Odds Ratio: 1.268 (95% CI 1.07–1.502)
p-value: p=0.006
May inform selective glucose screening in PCOS; observational data leaves causal and interventional implications open.
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and chronic anovulation, and it is one of the most common endocrine disorders, affecting 5% to 10% of reproductive age women [1]. Although the etiology of the syndrome is complex, insulin resistance and hyperinsulinemia are thought to play a major role in the pathophysiology of PCOS. Insulin resistance is thought to be caused by obesity, although recent studies have found that underweight women with PCOS are more likely to show insulin resistance than a normal control group. These results suggest that PCOS is independent of body weight for underweight women, although it is widely accepted that obesity is a key factor in insulin resistance in the general population. Prevalence rates PREDICTORS OF ABNORMAL GLUCOSE TOLERANCE AMONG WOMEN WITH POLYCYSTIC OVARY SYNDROME
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Koh et al. (2012) conducted a cross-sectional in Polycystic ovary syndrome (PCOS) (n=138). Fasting insulin vs. Lower fasting insulin was evaluated on Abnormal glucose tolerance (AGT) (OR 1.268, 95% CI 1.070-1.502, p=0.006). Higher fasting insulin (OR 1.268), BMI, age, and triglycerides were significant predictors of abnormal glucose tolerance, which was present in 48.2% of women with PCOS.
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