Aqueous and alcoholic extracts of Artemisia annua L. improved insulin resistance via decreasing TNF-alpha, IL-6 and free fatty acids in high-fat diet/streptozotocin-induced diabetic mice.

Mahshid Ghanbari; Forouzan Sadeghimahalli

doi:10.22038/ajp.2021.18829

January 1, 2022Open Access

Aqueous and alcoholic extracts of Artemisia annua L. improved insulin resistance via decreasing TNF-alpha, IL-6 and free fatty acids in high-fat diet/streptozotocin-induced diabetic mice.

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Key Points

To evaluate the therapeutic impact of aqueous and alcoholic extracts of Artemisia annua on insulin resistance, lipid profiles, and inflammatory cytokines in diabetic mice.
High-fat diet and streptozotocin-induced diabetic mice received oral daily treatments for four weeks with Artemisia annua extracts (hot-water, cold-water, or alcoholic at 100, 200, and 400 mg/kg), metformin (250 mg/kg), or served as untreated controls.
Serum biomarkers including free fatty acids, LDL/HDL ratio, TNF-alpha, IL-6, and the homeostasis model assessment of insulin resistance (HOMA-IR) were quantified post-treatment.
All Artemisia annua extracts across all doses and metformin significantly decreased serum free fatty acids, TNF-alpha, IL-6, LDL/HDL ratio, and HOMA-IR relative to untreated diabetic mice (p<0.0001).
The 400 mg/kg cold-water extract reduced TNF-alpha (p<0.01) and IL-6 (p<0.05) more effectively than metformin.

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Implication

Preclinical study reveals Artemisia annua extracts reduce insulin resistance and systemic inflammation in diabetic mice, suggesting therapeutic potential for metabolic disorders.

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Ghanbari et al. (2022) studied this question.

synapsesocial.com/papers/6ab8e448a64c6f94904eca2e https://doi.org/10.22038/ajp.2021.18829

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Aqueous and alcoholic extracts of Artemisia annua L. improved insulin resistance via decreasing TNF-alpha, IL-6 and free fatty acids in high-fat diet/streptozotocin-induced diabetic mice.

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Aqueous and alcoholic extracts of Artemisia annua L. improved insulin resistance via decreasing TNF-alpha, IL-6 and free fatty acids in high-fat diet/streptozotocin-induced diabetic mice.

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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