Key result
Prasugrel links to double the rate of in-hospital ADPri switching compared to clopidogrel.
Why the study?
Little is known about the frequency and factors associated with in-hospital switching between clopidogrel and prasugrel among patients with myocardial infarction treated with PCI in clinical practice.
What are the frequency and factors associated with in-hospital switching between clopidogrel and prasugrel in patients with acute myocardial infarction treated with percutaneous coronary intervention?
Population
47,040 myocardial infarction patients treated with PCI at 361 US hospitals from July 2009 to June 2011
Comparison
In-hospital switching between clopidogrel and prasugrel
Design
Observational study using merged registry databases with hierarchical logistic regression modeling
Follow-up
In-hospital
Authors
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Switching between ADP receptor inhibitors occurs with identifiable factors after MI PCI; leaves open whether patterns affect outcomes in practice.
Observational (n=47,040)
Yes
What are the frequency and factors associated with in-hospital switching between clopidogrel and prasugrel in patients with acute myocardial infarction treated with percutaneous coronary intervention?
In-hospital switching between clopidogrel and prasugrel is relatively common and is driven by a combination of ischemic risk, bleeding risk, and medical drug coverage.
Bagai et al. (2014) conducted an observational in Acute Myocardial Infarction (n=47,040). In-hospital switching between clopidogrel and prasugrel vs. Continuation of initial therapy was evaluated on In-hospital ADPri switching. In-hospital switching of ADP receptor inhibitors occurred in 5.2% of patients initially treated with clopidogrel and 11.5% of those initially treated with prasugrel.
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