A CRISPR-Based Humanized Model Reveals Cooperative Role of STAG2 Loss in Familial GATA2-Deficient MDS Progression

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness2025 · 4 citations
2. 2Impaired DNA damage response and inflammatory signalling underpins hematopoietic stem cell defects in<i>Gata2</i>haploinsufficiency2024
3. 3Hematological phenotypes in GATA2 deficiency syndrome arise from secondary injuries and maladaptation to proliferation2024 · 1 citations
4. 4Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome2025
5. 5STAG2 mutation preserves a stem cell phenotype in FLT3-ITD-mediated MDS to leukemia transformation2025