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September 19, 2025

Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome

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Authors

VSVarun SudunaguntaColumbia University Irving Medical CenterESEdna M. StewartUniversity of MissouriYCYi ChenJinhua Academy of Agricultural Sciences

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Implication

Observational analysis reveals altered Gata1 target gene expression in Stag2-deficient erythroid cells, suggesting connections to myelodysplastic syndrome.

Key Points

  • Stag2 deficiency leads to diminished erythroid output and increased megakaryocyte output, highlighting its role in hematopoiesis.
  • RNA- and ATAC-sequencing reveal altered Gata1 target gene expression associated with chromatin accessibility changes.
  • Defects in Stag2-deficient hematopoiesis include reduced erythroid progenitors and impaired maturation during erythropoiesis.
  • Human MDS models replicate critical phenotypic features observed in the murine Stag2-deficient models, indicating translational relevance.

Cite This Study

Sudunagunta et al. (2025) studied this question.

synapsesocial.com/papers/68d466b531b076d99fa6558chttps://doi.org/10.1101/2025.09.15.676332
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Also Consider

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