Key result
[⁶⁸Ga]Ga-DPI-4452 CAIX-targeted PET/CT detects latent multisystem tumor burden missed by other tracers in VHL syndrome.
Case Report (n=1)
CAIX-targeted PET/CT imaging can visualize pervasive hypoxia-induced phenotypes in VHL-associated neoplasms, detecting biologically active but metabolically latent disease.
May detect occult VHL tumors missed by standard imaging; hypothesis-generating and requires prospective validation before clinical adoption.
Von Hippel-Lindau (VHL) is hereditary syndrome characterized with benign and malignant neoplasms resulting from dysregulation of hypoxia-sensitive pathway. Fifty-year-old man with VHL underwent multimodal imaging for remaining CNS disease. ⁶⁸Ga-DOTATATE PET/CT showed single cerebellar lesion, while ¹⁸F-FDG PET/CT remained negative despite active disease; [⁶⁸Ga]Ga-DPI-4452 CAIX-targeted PET/CT revealed multisystem tumor burden; cerebellar and spinal hemangioblastomas, recurrent and contralateral ccRCC lesions and epididymal involvement. This case demonstrates the ability of CAIX-targeted imaging to visualize the pervasive hypoxia-induced phenotype underlying VHL-associated neoplasms, detect biologically active but metabolically latent disease, and may represent promising molecular imaging approach for phenotype-focused evaluation of inherited tumor syndromes.
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Arslan et al. (2026) conducted a case report in Von Hippel-Lindau (VHL) syndrome (n=1). [⁶⁸Ga]Ga-DPI-4452 CAIX-targeted PET/CT vs. ⁶⁸Ga-DOTATATE PET/CT and ¹⁸F-FDG PET/CT was evaluated on Detection of multisystem tumor burden. [⁶⁸Ga]Ga-DPI-4452 CAIX-targeted PET/CT revealed multisystem tumor burden in a patient with VHL syndrome, detecting biologically active but metabolically latent disease missed by other tracers.
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