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September 28, 2026Blood

HIF-1α/ADPGK-driven glycolytic reprogramming provokes platelet hyperactivation by fueling RHOA lactylation

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Authors

QLQigang LanYWYaqin WangMXMinhua Xie

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Lan et al. (2026) studied this question.

synapsesocial.com/papers/6ab9b5737822ec8fc3d902e8https://doi.org/10.1182/blood.2026033745
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  1. 1Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents2018 · 80 citations
  2. 2Hypoxia suppresses platelet activity through GPVI downregulation but paradoxically enhances arterial thrombosis via elevated vWF2026 · 1 citations
  3. 3Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension2022 · 130 citations
  4. 4Upregulation of coagulation pathway and enhanced platelet activity in hypoxia-exposed rat blood2026
  5. 5Hypoxia-induced histone lactylation promotes pulmonary arterial smooth muscle cells proliferation in pulmonary hypertension2025 · 17 citations