A tetrabutylammonium iodide (TBAI)-catalyzed oxidative coupling reaction between ethers and quinazoline-3-oxides is described. The transformation proceeds under mild, metal-free conditions using tert-butyl hydroperoxide (TBHP) as the oxidant. This simple and efficient protocol enables the convenient synthesis of structurally diverse quinazolin-4(3H)-one derivatives with moderate to excellent yields.
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Zhou et al. (2026) studied this question.
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