What does this research mean for the field?

Individual blood lipid parameters demonstrate distinct, transition-specific associations with progression to cardiometabolic multimorbidity, including elevated triglycerides increasing risk following coronary heart disease, with heterogeneous patterns across East Asian and European cohorts. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To examine how specific blood lipid parameters affect the progressive transition from health to single cardiometabolic diseases and subsequently to cardiometabolic multimorbidity across East Asian and European populations.

September 28, 2026ViewOpen Access

Different blood lipid profiles and their role in cardiometabolic disease progression: A comparative study between an East Asian and European Large Prospective Cohorts

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Cardiometabolic multimorbidity (CMM) (n=484028). Intervention: Blood lipid profiles (LDL-C, TG, TC, HDL-C, non-HDL-C). Primary outcome: Transitions from a CMD-free state to individual CMDs and subsequently to CMM (HR 1.21, 95% CI 1.01-1.44).

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Key result

Higher triglycerides linked to ~21% increased risk of post-CHD cardiometabolic multimorbidity.

HR 1.21
95% CI 1.01-1.44
n=484,028

Population

95,711 Kailuan study participants and 388,317 UK Biobank participants

Comparison

Associations of LDL-C, TG, TC, HDL-C, and non-HDL-C with cardiometabolic disease progression

Design

Comparative cohort study using multi-state models

Authors

LHLili HuangWuhan Dongxihu District People Hospital ZHZhe HuangKailuan General Hospital FMFandi MoShanghai Medical College of Fudan University

Discussion

Member takes

Implication

Prospective cohort study reveals distinct blood lipid associations with cardiometabolic multimorbidity progression in East Asian and European adults, highlighting transition-specific risks.

Key Points

To examine how specific blood lipid parameters affect the progressive transition from health to single cardiometabolic diseases and subsequently to cardiometabolic multimorbidity across East Asian and European populations.
Analyzed prospective cohort data from 95,711 participants in the Kailuan study and 388,317 participants in the UK Biobank.
Evaluated transitions from a disease-free baseline to individual cardiometabolic diseases (coronary heart disease, stroke, type 2 diabetes) and cardiometabolic multimorbidity using multi-state models.
Assessed five lipid parameters: low-density lipoprotein cholesterol, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol.
Lipid parameters were associated with initial onset of coronary heart disease or type 2 diabetes but showed limited association with overall stroke risk across cohorts.
In the Kailuan cohort, higher triglycerides (HR, 1.21; 95% CI, 1.01–1.44) and total cholesterol (HR, 1.13; 95% CI, 1.04–1.23) increased multimorbidity risk following coronary heart disease, and triglycerides increased risk following diabetes (HR, 1.05; 95% CI, 1.00–1.11).
In UK Biobank, higher LDL-C increased multimorbidity risk following diabetes (HR, 1.27; 95% CI, 1.03–1.57), while higher triglycerides (HR, 1.10; 95% CI, 1.07–1.14) and non-HDL-C (HR, 1.33; 95% CI, 1.15–1.54) increased post-coronary risk, and HDL-C was protective (HR, 0.90; 95% CI, 0.86–0.95).

Study Design

Type

Cohort (n=484,028)

Multicenter

Yes

PICO

Population

484,028 participants from the East Asian Kailuan study and the European UK Biobank evaluated for associations between lipid parameters and cardiometabolic disease progression.

Exposure / Comparator

Blood lipid profiles (LDL-C, TG, TC, HDL-C, non-HDL-C)

Primary Outcome

Transitions from a CMD-free state to individual CMDs and subsequently to CMM — HR 1.21 (1.01-1.44)

Main Result

Hazard Ratio: 1.21 (95% CI 1.01–1.44)

Cite This Study

Huang et al. (2026) conducted a cohort in Cardiometabolic multimorbidity (CMM) (n=484,028). Blood lipid profiles (LDL-C, TG, TC, HDL-C, non-HDL-C) was evaluated on Transitions from a CMD-free state to individual CMDs and subsequently to CMM (HR 1.21, 95% CI 1.01-1.44). Higher triglycerides were associated with increased risk of cardiometabolic multimorbidity following coronary heart disease in the Kailuan cohort (HR 1.21; 95% CI 1.01-1.44).

synapsesocial.com/papers/6ab9b5b87822ec8fc3d90bd0 https://doi.org/10.1002/viw2.70205

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Implication

Prospective cohort study reveals distinct blood lipid associations with cardiometabolic multimorbidity progression in East Asian and European adults, highlighting transition-specific risks.

Different blood lipid profiles and their role in cardiometabolic disease progression: A comparative study between an East Asian and European Large Prospective Cohorts

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Different blood lipid profiles and their role in cardiometabolic disease progression: A comparative study between an East Asian and European Large Prospective Cohorts

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Also Consider

Also Consider