Key result
Higher serum triglyceride concentrations were associated with a higher risk of coexisting type 2 diabetes and coronary heart disease (HR 1.99; 95% CI 1.12-3.53).
Why the study?
Blood lipids, apolipoproteins, and lipid ratios predict certain chronic diseases, but their association with cardiometabolic multimorbidity is less known.
Are lipid profiles and lipid ratios associated with the risk of incident cardiometabolic multimorbidity in men?
Population
1728 men aged 52.5 ± 5.2 years from the Kuopio Ischaemic Heart Disease study
Comparison
Varying blood levels of lipid profiles, apolipoproteins, and lipid ratios
Design
Cohort study
Follow-up
Mean follow-up of 22.4 years
Authors
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Supports triglyceride monitoring for multimorbidity risk in men; leaves open causality and need for interventional trials.
Cohort (n=1,728)
Are lipid profiles and lipid ratios associated with the risk of incident cardiometabolic multimorbidity in men?
Hazard Ratio: 1.99 (95% CI 1.12–3.53)
Elevated triglycerides, VLDL-C, and specific lipid ratios are independently associated with a higher risk of coexisting type 2 diabetes and coronary heart disease in men.
Tajik et al. (2022) conducted a cohort in Cardiometabolic multimorbidity (CMM) (n=1,728). Elevated serum triglycerides vs. Lower serum triglycerides was evaluated on Coexisting type 2 diabetes mellitus and coronary heart disease (T2D-CHD) (HR 1.99, 95% CI 1.12-3.53). Higher serum triglyceride concentrations were associated with a higher risk of coexisting type 2 diabetes and coronary heart disease (HR 1.99; 95% CI 1.12-3.53).
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