Key result
Levothyroxine normalizes QT interval and abolishes ventricular tachycardia in severe hypothyroidism.
Why the study?
There are few reports of torsades de pointes as the first presentation of long QT syndrome in the course of hypothyroidism.
Case Report (n=1)
No
Answers are grounded in this paper and cite their sources.
Severe hypothyroidism can present with acquired long QT syndrome and Torsades de pointes, which is reversible with levothyroxine replacement therapy.
BACKGROUND: Hypothyroidism can manifest with cardiac abnormalities, often consisting of a combination of morphologic and functional changes. Low voltage, sinus bradycardia, and slowed conduction are usually found on electrocardiography.There are few reports of occurrence of torsades de pointes as the first presentation of long QT syndrome in the course of hypothyroidism. CASE PRESENTATION: In present report we briefly describe a 50-years-old woman with severe hypothyroidism who presented with presyncope, prolongation of the QT interval, and polymorphic ventricular tachycardia (torsades de pointes). CONCLUSION: Our patient responded well to treatment with levothyroxine and QT intervals normalized and ventricular tachycardia was abolished two months after levothyroxine therapy.
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Shojaie et al. (2008) conducted a case report in Primary hypothyroidism with Torsades de pointes (n=1). Levothyroxine was evaluated on Normalization of QT interval and abolition of ventricular tachycardia. Treatment with levothyroxine normalized the QT interval and abolished ventricular tachycardia two months after therapy in a patient with severe primary hypothyroidism.
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