Key result
Children with ADHD exhibited significantly higher permutation entropy values in the right dorsolateral prefrontal cortex during a working memory task compared to healthy controls.
Why the study?
Does complexity analysis of fNIRS signals using permutation entropy differentiate children with ADHD from normal controls?
Case-Control (n=31)
No
Does complexity analysis of fNIRS signals using permutation entropy differentiate children with ADHD from normal controls?
p-value: p=0.027
Permutation entropy of fNIRS signals during working memory tasks shows potential as a diagnostic biomarker for ADHD in children.
May support fNIRS permutation entropy as ADHD biomarker; hypothesis-generating and requires prospective validation before clinical use.
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in children. Neuroimaging studies have revealed abnormalities of neural activities in some brain regions, including the frontal cortex, striatum, cerebellum, and occipital cortex. Recently, some investigators have demonstrated that nonlinear complexity analysis of neural activity may provide a new index to indicate ADHD. In the present study, we used the permutation entropy (PE) to measure the complexity of functional near-infrared spectroscopy (fNIRS) signals in children with and without ADHD during a working memory task, it was aimed to investigate the relationship between the PE values and the cortical activations, and the different PE values between the children with and without ADHD. We found that PE values exhibited significantly negative correlation with the cortical activations (r = -0.515, p = 0.003), and the PE values of right dorsolateral prefrontal cortex in ADHD children were significantly larger than those in normal controls (p = 0.027). In addition, the PE values of right dorsolateral prefrontal cortex were positively correlated to the ADHD index (r = 0.448, p = 0.012). These results suggest that complexity analysis of fNIRS signals could be a promising tool in diagnosing children with ADHD.
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Gu et al. (2017) conducted a case-control in Attention-deficit/hyperactivity disorder (ADHD) (n=31). Attention-deficit/hyperactivity disorder (ADHD) vs. Healthy controls was evaluated on Permutation entropy (PE) values of right dorsolateral prefrontal cortex during 1-back task (p=0.027). Children with ADHD exhibited significantly higher permutation entropy values in the right dorsolateral prefrontal cortex during a working memory task compared to healthy controls.
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