Key result
Loop diuretics linked to ~110% higher risk of hypokalemia in heart failure.
Why the study?
Hypokalemia is a frequent and clinically important electrolyte disturbance in heart failure patients on diuretic therapy, but its occurrence and predictors need evaluation.
Population
150 hospitalized heart failure patients on loop or thiazide diuretics for at least one week
Comparison
Hypokalemic (K < 3.5 mmol/L) vs normokalemic (K ≥ 3.5 mmol/L) patients
Design
Cross-sectional study
Authors
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May warrant closer K+ monitoring in HF on loop diuretics; hypothesis-generating and needs prospective confirmation.
Cross-Sectional (n=150)
No
Odds Ratio: 2.1 (95% CI 1.1–4)
p-value: p=0.023
Hypokalemia is highly prevalent (31.3%) among hospitalized heart failure patients on diuretics, with high-dose and loop diuretics being significant independent predictors.
Qaisar et al. (2025) conducted a cross-sectional in Heart failure (n=150). Loop diuretics vs. Thiazide diuretics was evaluated on Hypokalemia (serum potassium < 3.5 mmol/L) (OR 2.10, 95% CI 1.10-4.00, p=0.023). Loop diuretic use independently predicted a higher risk of hypokalemia in patients with heart failure (OR 2.10).
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