Key result
Acute decompensated heart failure is linked to cognitive decline in up to ~80% of hospitalized patients.
Why the study?
Cognitive decline is a prevalent and independent prognostic marker of unfavorable outcomes in heart failure patients, but requires more clinical attention.
Cognitive decline is a highly prevalent and prognostically important complication in heart failure that warrants routine clinical screening.
May warrant cognitive screening in acute HF; leaves open whether it improves outcomes without prospective trials.
Cognitive decline is a prevalent condition and independent prognostic marker of unfavourable outcomes in patients with heart failure. The highest prevalence, up to 80 %, is reported in patients hospitalised due to acute decompensation. Numerous factors contribute to cognitive dysfunction in heart failure patients, with hypertension, atrial fibrillation, stroke and impaired haemodynamics being the most relevant. Cerebral hypoperfusion, disruption of blood-brain barrier, oxidative damage and brain-derived cytokines are pathogenic links between heart failure and alteration of cognitive functioning. White matter hyperintensities, lacunar infarcts and generalised volume loss are common features revealed by neuroimaging. Typically affected cognitive domains are presented. Assessment of cognitive functioning, even by simple screening tests, should be part of routine clinical examination of heart failure patients.
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Čelutkienė et al. (2016) conducted a review in Heart failure and cognitive decline. Cognitive decline was evaluated. Cognitive decline affects up to 80% of patients hospitalized for acute decompensated heart failure, highlighting the need for routine cognitive screening in clinical practice.
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