Mitral annular calcification in patients with significant mitral valve disease: An old problem with new solutions
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Key result
TMVR emerges as a promising alternative to conventional surgery in severe mitral annular calcification.
Why the study?
Mitral annular calcification complicates treatment of significant mitral valve disease and poses risks with surgical and transcatheter interventions, requiring evaluation of new solutions.
Population
Patients with significant mitral valve disease and mitral annular calcification
Comparison
Surgical techniques versus transcatheter mitral valve replacement including Tendyne device
Design
Review
Authors
Discussion
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Implication
May offer a less invasive option for high-risk severe MAC; leaves open confirmation by randomized trials before practice change.
Structured PICO
P
Population
Patients with significant mitral valve disease and mitral annular calcification (MAC)
I
Intervention
Transcatheter mitral valve replacement (TMVR) (including Tendyne device) and surgical techniques
TMVR offers a promising, less invasive alternative to surgery for high-risk patients with severe mitral valve disease and mitral annular calcification.
Limitations
- Most available surgical series are old and small in size.
- Encouraging outcomes for Tendyne are the result of a very selective patient recruitment process with a screen failure rate of at least 40% due to unfavorable anatomy.
- Larger prospective studies are needed to confirm the available results.
Cite This Study
Ascione et al. (2022) conducted a review in Mitral annular calcification with significant mitral valve disease. Transcatheter mitral valve replacement (TMVR) and surgical interventions was evaluated. Transcatheter mitral valve replacement, particularly with the Tendyne system, has emerged as a promising alternative to conventional surgery for high-risk patients with severe mitral annular calcification.
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