Key result
Validated risk scores accurately predict mortality to effectively guide pulmonary arterial hypertension therapy.
Why the study?
Physicians need effective risk prediction tools in PAH to guide prognosis, therapy adjustments, and timely lung transplantation referral, improving patient outcomes.
Risk prediction in pulmonary arterial hypertension allows for informed therapy adjustments and timely lung transplant referral, aiming to reduce morbidity and mortality.
Supports risk-stratified PAH management; leaves open need for prospective validation of calculator-guided therapy.
[No abstract. Showing first paragraph of article]Pulmonary arterial hypertension (PAH) is a chronic disease of the pulmonary vasculature characterized by progressive narrowing of the pulmonary arteries leading to increased pulmonary vascular resistance, right heart failure, and ultimately premature death.There has been a significant improvement in the available medical therapeutic options in this field that have impacted the short-term survival and morbidity in these patients. However, the median survival post-diagnosis remains unacceptable at 7 years.Physicians’ ability to predict PAH disease progression and risk allows them to determine the patient’s prognosis, make informed adjustments to therapy, and monitor his or her response to therapy . If widely adopted, risk prediction can enhance the consistency of treatment approaches and improve the timeliness of referral for lung transplantation. This approach should lead optimal, directed care that ultimately reduces morbidity and improves mortality in patients with PAH.
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Paul A. Corris (2020) conducted a review in Pulmonary arterial hypertension. Risk stratification tools (e.g., REVEAL, ESC/ERS guidelines) was evaluated. Risk assessment using validated calculators such as REVEAL and ESC/ERS guidelines is effective at predicting mortality and prognosis to guide appropriate treatment in patients with pulmonary arterial hypertension.
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