Key result
ACE2 G8790A polymorphism shows no association with the risk of basal cell carcinoma.
Why the study?
The influence of the ACE2 G8790A functional polymorphism on the pathogenesis of basal cell carcinoma was unclear.
Is the ACE2 G8790A functional polymorphism associated with the pathogenesis of basal cell carcinoma?
Case-Control (n=190)
Is the ACE2 G8790A functional polymorphism associated with the pathogenesis of basal cell carcinoma?
The ACE2 G8790A polymorphism does not appear to be associated with the risk of developing basal cell carcinoma in a Greek population.
No association in this Greek case-control study; leaves open ACE2 variants' role in basal cell carcinoma across populations.
BACKGROUND/AIM: The G8790A (rs2285666) functional polymorphism of the angiotensin-converting enzyme 2 (ACE2) gene influences alternative mRNA splicing and quantitatively affects the enzyme's production. Specifically, the presence of the A allele has been associated with higher ACE2 plasma levels. In this study, we investigated the possible association of the functional polymorphism ACE2-G8790A with the pathogenesis of basal cell carcinoma (BCC). PATIENTS AND METHODS: A total of 190 DNA samples were studied, including 91 BCC patients and 99 controls of Greek origin. Molecular genotyping for the ACE2 G8790A polymorphism was carried out by PCR amplification, followed by AluI enzyme digestion and agarose gel electrophoresis of the DNA fragments. RESULTS: The allelic and genotypic frequencies presented no statistical difference between the patient and the control group. CONCLUSION: There is no association between the ACE2 G8790A polymorphism and pathogenesis of BCC.
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Gintoni et al. (2021) conducted a case-control in Basal cell carcinoma (n=190). ACE2 G8790A polymorphism vs. Controls without basal cell carcinoma was evaluated on Allelic and genotypic frequencies. The ACE2 G8790A polymorphism was not associated with the pathogenesis of basal cell carcinoma, showing no statistical difference in allelic and genotypic frequencies between groups.
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