Why the study?
Is the ACE2 G8790A polymorphism associated with essential hypertension in a Chinese Han population?
Is the ACE2 G8790A polymorphism associated with essential hypertension in a Chinese Han population?
The ACE2 G8790A polymorphism does not appear to be a genetic risk factor for essential hypertension in the Chinese Han population.
Does not support ACE2 G8790A testing for hypertension risk assessment; leaves open other genetic contributors in Chinese Han and broader populations.
INTRODUCTION: We performed a meta-analysis to assess the association of ACE2 G8790A polymorphism with essential hypertension. MATERIALS AND METHODS: The references were retrieved through MEDLINE, Wanfang and VIP Information.The analyses were performed by the software STATA 9.0. RESULTS: No significant publication bias was observed.The combined data showed no association of the frequencies of the A allele with essential hypertension odds ratio (OR)=1.09 95% confidence interval (CI)=0.98-1.20;p=0.11 in female patients. No associations were shown between the frequencies of the A allele with the genetic susceptibility to essential hypertension in male patients (OR=1.11 95% CI=0.95-1.29; p=0.19). CONCLUSION: The meta-analysis suggests that ACE2 G8790A polymorphism may not be a genetic risk factor for essential hypertension in a Chinese Han population.
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Zhou et al. (2009) studied this question.
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