New C-N-C Bond Formation Reaction Using Nitrogenation-Transmetallation Process. Novel Ring Construction of Indole and Quinoline Derivatives

Ketones and aryl or vinyl halides couple to give divinyl-or arylvinylamines in the presence of the titaniumisocyanate complex [3THF.Mg2C120.TiNCO]( 1 ) and a palladium catalyst, v i a transmetallation of the titano imine complex (3) with aryl-or vinylpalladium bromide.Over the past two decades molecular nitrogen fixation has intrigued many research g r o u p . 1The nitrogenation method by use of titanium-nitrogen complex2developed by us3 is one of the earliest indication of the applicability of transition metal nitrogen complexes in organic synthesis as an NI unit reagent(l).3b