Synthesis and property of a novel calcium phosphate cement

The beta-cyclodextrins (beta-CDs) and amorphous calcium phosphate were used to prepare a novel calcium phosphate cement (CPC) after mechanochemical activation. Under the mechanochemical treatment, hydrogen bonding formed between beta-CD molecules, which induced strong interaction among beta-CD molecules in aqueous solution, thus conferring good antiwashout property for CPC. After mechanochemical treatment, the solubility of beta-CD was increased and so beta-CD showed different behaviors within and on the outer surface of CPC. During the setting process, when beta-CD was injected it flowed to the surface of CPC, forming a beta-CD film on the surface of CPC; inside the cement, the hydration reaction of calcium phosphates was not affected. Moreover, the antiwashout CPC with beta-CD also showed good mechanical setting, rheological properties, and injectability. The novel CPC was supposed to be developed as a good injectable bone substitute material in the clinical application.