Key result
In 3 patients with takotsubo cardiomyopathy, brain SPECT demonstrated increased cerebral blood flow in the hippocampus, brainstem, and basal ganglia, and decreased flow in the prefrontal cortex at 1-4 days, which partially persisted at 28-39 days.
Findings from animal models of takotsubo cardiomyopathy should be carefully interpreted and translated into the clinical setting due to fundamental differences in brain structure between animals and humans.
tested in future studies.Fifth, of interest, animal models of takotsubo cardiomyopathy have already provided evidence for the of stress or epinephrine in the pathogenesis of the disorder. 9,10However, the major limitation of the animal models with takotsubo cardiomyopathy is that there are fundamental differences in the structure of the brains of animals and humans. 11Thus, the findings obtained in the animal models of takotsubo thy should be carefully interpreted and translated into the clinical setting.
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Suzuki et al. (2014) conducted a letter in Takotsubo cardiomyopathy (n=3). Brain SPECT imaging was evaluated on Cerebral blood flow (CBF) alterations. In 3 patients with takotsubo cardiomyopathy, brain SPECT demonstrated increased cerebral blood flow in the hippocampus, brainstem, and basal ganglia, and decreased flow in the prefrontal cortex at 1-4 days, which partially persisted at 28-39 days.
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