Key result
Antipsychotic medications are linked to increased risk of QT prolongation and torsades de pointes.
Why the study?
Antipsychotic medications are associated with prolonged QT interval and risk of torsades de pointes, necessitating assessment of risks before prescribing.
What are the risks of prolonged QT interval and torsades de pointes associated with antipsychotic medications, and how should they be managed?
What are the risks of prolonged QT interval and torsades de pointes associated with antipsychotic medications, and how should they be managed?
Comprehensive risk assessment is essential prior to prescribing antipsychotic medications to mitigate the risk of prolonged QT interval and torsades de pointes.
Supports pre-prescription QT assessment in at-risk patients; leaves open absolute risk quantification and optimal mitigation strategies.
Antipsychotic medications are widely prescribed by advanced clinical practitioners (ACPs), to treat a range of presentations. They are licensed for the treatment of schizophrenia, bipolar disorder and depression. They are also widely used off-license as anxiolytics, as well as to help manage presenting symptoms of borderline personality. These drugs are associated with prolonged QT interval, which is a risk factor for the ventricular tachyarrhythmia, torsades de pointes (TdP), which can lead to sudden cardiac death. Although TdP is rare, this review examines the condition and discusses the importance of assessing the physical, pharmacological and psychiatric risks prior to prescribing antipsychotic medications.
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Kemp et al. (2023) conducted a review in Patients prescribed antipsychotic medications. Antipsychotic medications was evaluated on Prolonged QT interval and torsades de pointes (TdP). Antipsychotic medications are associated with prolonged QT interval and torsades de pointes, necessitating thorough physical, pharmacological, and psychiatric risk assessment prior to prescribing.
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