Key result
Rising serum uric acid levels are linked to ~6% lower metabolic syndrome risk in males.
Why the study?
It has not been determined whether changes in serum uric acid level are associated with incident metabolic syndrome.
Does an increase in serum uric acid level prevent the development of metabolic syndrome in subjects without baseline metabolic syndrome?
Cohort (n=13,057)
No
Does an increase in serum uric acid level prevent the development of metabolic syndrome in subjects without baseline metabolic syndrome?
Hazard Ratio: 0.944 (95% CI 0.906–0.982)
p-value: p=0.005
Increasing serum uric acid levels may independently protect against the development of metabolic syndrome, potentially due to its antioxidant properties.
Rising uric acid levels were associated with lower metabolic syndrome risk; hypothesis-generating and should not change practice without randomized confirmation.
Background: It has not been determined whether changes in serum uric acid (SUA) level are associated with incident metabolic syndrome (MetS).The aim of the current study was to investigate the relationship between changes in SUA level and development of MetS in a large number of subjects.Methods: In total, 13,057 subjects participating in a medical health check-up program without a diagnosis of MetS at baseline were enrolled.Cox proportional hazards models were used to test the independent association of percent changes in SUA level with development of MetS.Results: After adjustment for age, systolic blood pressure, body mass index, fat-free mass (%), estimated glomerular filtration rate, smoking status, fasting glucose, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and baseline SUA levels, the hazard ratios (HRs) (95% confidence intervals [CIs]) for incident MetS in the second, third, and fourth quartiles compared to the first quartile of percent change in SUA level were 1.055 (0.936 to 1.190), 0.927 (0.818 to 1.050), and 0.807 (0.707 to 0.922) in male (P for trend <0.001) and 1.000 (0.843 to 1.186), 0.744 (0.615 to 0.900), and 0.684 (0.557 to 0.840) in female (P for trend <0.001), respectively.As a continuous variable in the fully-adjusted model, each one-standard deviation increase in percent change in SUA level was associated with an HR (95% CI) for incident MetS of 0.944 (0.906 to 0.982) in male (P=0.005) and 0.851 (0.801 to 0.905) in female (P<0.001). Conclusion:The current study demonstrated that increasing SUA level independently protected against the development of MetS, suggesting a possible role of SUA as an antioxidant in the pathogenesis of incident MetS.
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Yu et al. (2019) conducted a cohort in Metabolic syndrome (n=13,057). Percent change in serum uric acid level vs. First quartile of percent change in serum uric acid level was evaluated on Incident metabolic syndrome (HR 0.944, 95% CI 0.906 to 0.982, p=0.005). Each one-standard deviation increase in percent change in serum uric acid level independently protected against the development of metabolic syndrome in males (HR 0.944) and females (HR 0.851).
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