Key result
miR-181a1/b1 deficiency increases pulse wave velocity ~26% and raises systolic blood pressure in mice.
Why the study?
The role of the miR-181 family in vascular stiffening and hypertension pathogenesis, particularly its regulation of TGF-β signaling with aging, was unclear.
Does miR-181b knockout increase vascular stiffness and blood pressure in mice?
Population
Eight miR-181a1/b1-/- mice and wild type C57BL6J mice
Comparison
miR-181a1/b1 knockout mice vs wild type mice, with losartan treatment in knockout mice
Design
Preclinical experimental study
Follow-up
21 weeks
Authors
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Hypothesis-generating in mice; leaves open whether miR-181b modulation affects human vascular stiffness or hypertension.
Does miR-181b knockout increase vascular stiffness and blood pressure in mice?
Absolute Event Rate: 4.489% vs 3.562%
p-value: p=<0.0001
Decreased miR-181b expression contributes to age-dependent vascular stiffening and hypertension by upregulating TGF-β signaling, an effect that can be attenuated by losartan.
Hori et al. (2017) studied Vascular stiffness and hypertension (n=50). miR-181a1/b1 knockout vs. Wild-type mice was evaluated on Pulse wave velocity at 20 weeks (p=<0.0001). Mice deficient in miR-181a1/b1 exhibited a significant increase in pulse wave velocity (4.489 vs 3.562 m/sec) and systolic blood pressure at 20 weeks compared to wild-type mice.
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