Key result
Congenital heart disease linked to significantly lower vitamin D levels in children, especially in cyanotic cases.
Why the study?
25(OH) Vitamin D is hypothesized to be involved in cardiovascular disease due to its receptors in heart cells, but its serum levels in children with congenital heart disease were not well evaluated.
Are serum 25(OH) vitamin D levels lower in children with congenital heart disease compared to healthy controls?
Case-Control (n=100)
Are serum 25(OH) vitamin D levels lower in children with congenital heart disease compared to healthy controls?
Children with congenital heart disease, particularly those with cyanotic disease, have significantly lower serum 25(OH) vitamin D levels compared to healthy controls.
Answers are grounded in this paper and cite their sources.
Vitamin D levels in children with CHD merit exploration; leaves open any causal role or supplementation benefit.
Background & Aim: Identification of 25(OH) Vit D receptors in endothelial cells, smooth muscle cells, and myocytes from the heart has led to the hypothesis that this 25(OH) Vit D is involved in cardiovascular disease. The present study was designed to evaluate 25-hydroxy Vitamin D serum levels in congenital heart disease (CHD) children compared to controls. Methods: This case control study included 100 children, divided into 2 groups, Group (A) included 60 children with CHD who were divided into two groups (cyanotic and acyanotic). And group (B) included 40 apparently healthy children as a control group. All patients included in the study were subjected to the following: complete history taking and physical examination, echocardiography, and serum 25 (OH) vitamin D levels. Results: The mean serum.25 (OH) vitamin D level was significant lower in the CHD group than control group . the Serum.25 (OH) vitamin D level was significant lower in cyanotic group than acyanotic patients . there were a statistically significant difference between Serum.25 (OH) vitamin D level with various age groups of cyanotic and acyanotic patients. Conclusion: The serum level of 25(OH) Vit D was lower in CHD children, and among the patients, was lower in cyanotic. So it should be checked in CHD children especially those who suffered from cyanotic heart disease.
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Rahman et al. (2022) conducted a case-control in Congenital heart disease (n=100). Congenital heart disease vs. Healthy controls was evaluated on Serum 25-hydroxy Vitamin D levels. Congenital heart disease in children was associated with significantly lower serum 25(OH) Vitamin D levels compared to healthy controls, particularly in those with cyanotic heart disease.
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