Key result
Electrophysiological profiling resolves four distinct outward potassium currents in ventricular myocytes, identifying novel I(Kx).
Why the study?
Although two Ca(2+)-insensitive K(+) current components were known in rat ventricle, electrophysiological evidence for additional outward current components was lacking.
This study identifies four distinct components of outward potassium currents in rat ventricular myocytes, including a novel current I(Kx).
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Adds electrophysiological evidence for K+ current diversity in rat ventricle; leaves open relevance to human cardiac electrophysiology.
Himmel et al. (1999) studied Rat ventricular myocytes. Whole cell voltage-clamp and pharmacological agents was evaluated on Outward current components. Electrophysiological and pharmacological analysis of rat ventricular myocytes identified at least four distinct components contributing to outward potassium current: I(to), I(K), I(ss), and a novel I(Kx).
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