Key result
VEGF inhibitors are linked to hypertension, requiring routine blood pressure monitoring and management.
Why the study?
VEGF inhibitors have revolutionized cancer treatment but are significantly associated with hypertension as an adverse effect, and optimal management of this hypertension remains unclear.
Do VEGF inhibitors cause hypertension in cancer patients and how should it be managed?
Do VEGF inhibitors cause hypertension in cancer patients and how should it be managed?
VEGFi therapy is significantly associated with hypertension, requiring careful blood pressure monitoring and management strategies in cardio-oncology.
May warrant BP monitoring with VEGF inhibitors; leaves open optimal strategies pending prospective trials.
The introduction of therapies that inhibit tumor angiogenesis and particularly target to vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) (VEGF inhibitors/VEGFi) have revolutionized the treatment of various cancer types. Although their clinical benefit can be optimal for cancer-affected patients, the safety of these targeted agents is of special concern especially for longer-term adjuvant or maintenance treatment. Importantly, VEGFi therapy has been significantly associated with hypertension (HTN) as an adverse effect and therefore the control of blood pressure (BP) after the administration of these drugs remains a challenging matter to be faced. The aim of this review is to summarize studies which investigate the association of VEGFi agents with HTN manifestation and the possible risks associated with this complication. Additionally, given that the optimal management of HTN caused by VEGFi remains obscure, this review will focus on prevention strategies including BP monitoring plans and propose potential therapeutic approaches.
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Katsi et al. (2015) conducted a review in Cancer. VEGF inhibitors was evaluated on Hypertension manifestation. VEGF inhibitor therapy is significantly associated with hypertension as an adverse effect, necessitating careful blood pressure monitoring and management.
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