Key result
Aging does not alter discrete baroreflex sensitivity but eliminates cardiopulmonary and carotid baroreflex interaction.
Why the study?
Aging may diminish baroreflex function during central hypovolemia, but this has not been clearly established.
Does aging diminish baroreflex function during central hypovolemia induced by lower body negative pressure?
Population
Eleven healthy young (18-36 yr) and eleven older (60-69 yr) individuals
Comparison
Responses to neck pressure and suction during rest and LBNP of -15 Torr between young and older groups
Design
Observational study assessing baroreflex sensitivity
Authors
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Loss of cardiopulmonary-carotid baroreflex interaction with aging during hypovolemia may affect stability; hypothesis-generating and requires prospective confirmation before clinical consideration.
Observational (n=22)
Does aging diminish baroreflex function during central hypovolemia induced by lower body negative pressure?
Absolute Event Rate: -3.7% vs -3.6%
Aging alters the central integration of afferent neural inputs from discrete baroreceptors during central hypovolemia, as evidenced by the lack of interaction between cardiopulmonary and carotid baroreflexes in older individuals.
Shi et al. (1996) conducted an observational in Healthy (n=22). Older age (60-69 years) vs. Young age (18-36 years) was evaluated on Cardiopulmonary baroreflex sensitivity (units/mmHg). Older age did not alter discrete cardiopulmonary (-3.7 vs -3.6 units/mmHg) or carotid baroreflex sensitivity compared to young age, but their interaction was absent in older subjects.
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