Nail pigmentation may be an early sign of minocycline-associated cutaneous pigmentation: A systematic review

This is the authors' abstract. We don't add key points for this paper.

To the Editor: Minocycline, a broad-spectrum tetracycline antibiotic with anti-inflammatory properties, is often prescribed for dermatologic indications, but use is limited due to the feared complication of cutaneous pigmentation, which may be permanent.1,2 There are potential associations of hyperpigmentation with older age and higher daily and cumulative minocycline doses, though evidence is sparse.3 Therefore, we aimed to systematically review data on minocycline-associated pigmentation to identify characteristics associated with hyperpigmentation development.