Key result
Albuminuria is linked to calcified atherosclerotic plaque in African Americans with diabetes.
Why the study?
It remains unclear whether ethnic differences exist in the effect of albuminuria on risk for development and progression of calcified atherosclerotic plaque in African Americans with diabetes.
Does albuminuria associate with calcified atherosclerotic plaque in African Americans with diabetes?
Observational
Does albuminuria associate with calcified atherosclerotic plaque in African Americans with diabetes?
The study investigates the association between albuminuria and calcified atherosclerotic plaque in African Americans with diabetes to clarify ethnic differences in atherosclerosis risk.
Albuminuria associates with CP in AAs with T2D; leaves open whether it explains ethnic plaque differences or warrants targeted screening.
Relative to individuals with European ancestry, presence and severity of calcified atherosclerotic plaque (CP) are markedly lower in individuals with African ancestry (1,2). Factors potentially contributing to the ethnic variation in susceptibility to atherosclerosis include different relationships between CP and serum 25 hydroxyvitamin D concentrations and pericardial adipose tissue volumes in African Americans (AAs) relative to European Americans (EAs) (3,4). In addition, significant positive associations have been observed between CP and albuminuria in EAs with type 2 diabetes (5) but not AAs (419 subjects from 297 African American Diabetes Heart Study [AA-DHS] families) (6). Therefore, it remains unclear whether ethnic differences exist in the effect of albuminuria on risk for development and progression of CP. To improve power for detecting associations between …
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Divers et al. (2013) conducted an observational in Diabetes. Albuminuria was evaluated on Calcified atherosclerotic plaque (CP). Albuminuria is associated with calcified atherosclerotic plaque in African Americans with diabetes.
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