Key result
Home orthostatic hypertension is linked to a ~6-fold higher urinary albumin/creatinine ratio vs orthostatic hypotension.
Why the study?
There have been few reports on the clinical implications of orthostatic blood pressure changes detected by self-measured home blood pressure monitoring in hypertensive patients.
Does orthostatic hypertension detected by home blood pressure monitoring associate with increased BNP and urinary albumin excretion in hypertensive outpatients?
Cross-Sectional (n=605)
Yes
Does orthostatic hypertension detected by home blood pressure monitoring associate with increased BNP and urinary albumin excretion in hypertensive outpatients?
Absolute Event Rate: 209.1% vs 34.1%
p-value: p=0.003
Orthostatic hypertension detected by home blood pressure monitoring is associated with elevated BNP and urinary albumin excretion, suggesting it may be a novel cardiovascular risk factor in elderly hypertensives.
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May mark higher cardiorenal risk in hypertension; leaves open whether home BP orthostasis monitoring refines risk stratification.
Hoshide et al. (2008) conducted a cross-sectional in Hypertension (n=605). Orthostatic hypertension (OHT) detected by home blood pressure monitoring vs. Orthostatic hypotension (OHYPO) or orthostatic normotension (ONT) was evaluated on Urinary albumin/creatinine ratio (UAR) (p=0.003). Orthostatic hypertension detected by home blood pressure monitoring was associated with a significantly higher urinary albumin/creatinine ratio (209.1 vs 34.1 mg/g Cr) and brain natriuretic peptide levels compared to orthostatic hypotension.
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