Key result
Pregnancy-induced hypertension is linked to ~26% higher basal plasma hANP levels vs. normotensive pregnancy.
Why the study?
Plasma concentrations of human atrial natriuretic polypeptide (hANP) in pregnancy-induced hypertension (PIH) and their potential to differentiate PIH subpopulations were not well characterized.
Are plasma concentrations of human atrial natriuretic polypeptide (hANP) elevated in women with pregnancy-induced hypertension compared to normotensive pregnancies?
Comparison
PIH patients vs normotensive term pregnancies
Design
Observational study measuring plasma hANP concentrations
Authors
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May support hANP as a biomarker for pregnancy-induced hypertension; hypothesis-generating and should not yet change practice.
Observational (n=50)
Are plasma concentrations of human atrial natriuretic polypeptide (hANP) elevated in women with pregnancy-induced hypertension compared to normotensive pregnancies?
Absolute Event Rate: 378% vs 299%
p-value: p=<0.001
Plasma hANP concentrations are significantly elevated in a subset of patients with pregnancy-induced hypertension and may serve as a marker for the condition.
Cowan et al. (1988) conducted an observational in Pregnancy-induced hypertension (n=50). Pregnancy-induced hypertension vs. Normotensive term pregnancies was evaluated on Plasma concentrations of human atrial natriuretic polypeptide (hANP) (p=<0.001). Pregnancy-induced hypertension was associated with significantly higher mean basal plasma hANP concentrations compared to uncomplicated term pregnancies (378 vs 299 pg/ml; p < 0.001).
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