July 1, 1986AJP Heart and Circulatory Physiology
Ambulatory pulmonary arterial pressures in humans: relationship to arterial pressure and hormones
Key result
Ambulatory pulmonary pressure averages ~16/6 mmHg in healthy adults, paralleling systemic pressure during exercise.
- n=6
Why the study?
The normal range and variability of pulmonary artery pressure and its relationship to systemic arterial pressure and vasoactive hormones under standardized conditions in healthy humans were not well characterized.
Population
6 healthy volunteers
Comparison
Pulmonary artery pressure vs systemic arterial pressure at rest and during exercise, eating, hypoxia, and smoking
Design
Observational study with continuous ambulatory recording
Follow-up
8-10 hours
Authors
Discussion
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Implication
Preliminary ambulatory PA pressure data from healthy volunteers; leaves open validation in pulmonary hypertension and clinical utility.
Study Design
Type
Observational (n=6)
Structured PICO
P
Population
6 healthy volunteers studied over 8-10 hours using continuous ambulatory recording to document pulmonary artery pressure.
E
Exposure
Continuous ambulatory recording of pulmonary artery pressure (PAP) and systemic arterial pressure (SAP) at rest and during standardized interventions (exercise, eating, hypoxia, smoking)
O
Outcome
Normal range and variability of pulmonary artery pressure (PAP) and its relationship to systemic arterial pressure (SAP)surrogate
This study provides baseline physiological data on ambulatory pulmonary artery pressures and demonstrates that pulmonary and systemic pressures can respond divergently to specific stimuli like hypoxia.
Cite This Study
Richards et al. (1986) conducted an observational in Healthy volunteers (n=6). Standardized interventions (exercise, eating, hypoxia, smoking) vs. Rest was evaluated on Pulmonary artery pressure (PAP) and systemic arterial pressure (SAP). Continuous ambulatory recording in 6 healthy volunteers demonstrated a mean pulmonary artery pressure of 15.7/6.3 mmHg over 8-10 hours, which changed in parallel with systemic pressure during exercise but diverged during hypoxia.