Key result
Real-time arterial loading system successfully simulates dynamic vascular impedance loads on isolated ventricles.
Why the study?
A technique to study the real-time effects of arterial wave reflections on isolated left ventricular performance was needed.
Population
Isolated ferret heart
Comparison
Real-time arterial loading with asymmetric T-tube wave transmission model vs baseline loading
Design
Preclinical experimental study using multiprocessor computer control system
Authors
Loading...
Enables precise afterload studies in isolated ventricles; leaves open clinical translation pending validation.
A novel real-time arterial loading system enables the study of arterial wave reflection effects on isolated left ventricular function.
Kirkpatrick et al. (1991) studied this question. Real-time arterial loading with an asymmetric T-tube wave transmission model was evaluated on Real-time effects of arterial wave reflections on the performance of the isolated left ventricle. A real-time arterial loading system using a multiprocessor computer and linear motor pump successfully allowed the imposition of a wide variety of vascular impedances on the isolated ferret ventricle.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: